The Human 5.0 Project

The Human 5.0 Project is the podcast where science meets self-optimization. Hosted by Ultimate Biohacker 10X, this show explores the real research, real data, and real dosing behind today’s most effective biohacking tools — from peptides, longevity molecules, and nootropics to recovery devices, lifestyle strategies, sleep optimization, training principles, and cutting-edge performance tech.

Each episode breaks down complex biology into practical, actionable protocols you can use to improve energy, metabolism, cognition, and overall healthspan. No hype. No fluff. Just evidence-based insights for people who want to understand their bodies, upgrade their biology, and unlock their highest potential.

If you’re ready to optimize your life one pathway at a time, you’re in the right place.

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Episodes

14 hours ago

Part 2: Fix Insulin Resistance — Labs, Levers & Faster Fat Loss 2026
 
Insulin resistance is the silent brake on fat loss—especially stubborn belly fat—even when you're "doing everything right." In this Part 2 Biohacker Briefing on The Human 5.0 Project, UltimateBiohacker10X breaks down how to test it properly (fasting insulin, HOMA-IR, A1C, glucose), what the numbers really mean, and the 6-lever reset that actually improves insulin sensitivity without crash diets.
In this episode:
 
What insulin resistance is and why it locks belly fat
Clean lab stack: fasting insulin, HOMA-IR, A1C, glucose, lipids
How to interpret results without panic (trends > single numbers)
6-lever fix framework: sleep, meal structure, lifting, conditioning, steps, stress control
Supplements & meds: berberine, magnesium, clinician-guided options
Men vs women: cycle/estrogen influence + recovery priorities
30-Day Insulin Reset Challenge checklist
 
This is education only — not medical advice. Insulin resistance can signal prediabetes, PCOS, thyroid issues, or deeper conditions. Get clinician oversight and labs (fasting insulin, glucose, HbA1c, lipids, thyroid) if symptoms persist (fatigue after meals, cravings, dark skin patches, family diabetes history).
 
 
Open: The Invisible Brake
Intro & Disclaimer
What Insulin Resistance Really Is
How to Test It: Clean Lab Stack
How to Interpret Results Without Panicking
The 6-Lever Reset Framework
Supplements & Meds: Where They Fit
Close: 30-Day Insulin Reset Challenge
 
Part 1 (Stubborn Belly Fat): [link to Part 1]
 
 
🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#InsulinResistance #FixInsulinResistance #FatLoss #BellyFat #HOMA-IR #Biohacking #MetabolicHealth #InsulinSensitivity #Berberine #SleepForFatLoss #HIIT #Zone2Training #TheHuman50Project #UltimateBiohacker10X #HealthOptimization #Longevity #2026FatLoss #Prediabetes #PCOS #ThyroidHealth

17 hours ago

Stubborn Belly Fat: Why It’s Last to Leave + The 7-Lever Fix (Steps, Sleep, Insulin, Training + BHB)
 
Stubborn belly fat is the last to go—even when your arms, legs, and face are leaning out. In this Biohacker Briefing on The Human 5.0 Project, UltimateBiohacker10X breaks down why abdominal fat is physiologically protected (insulin, cortisol, alpha-2 receptors, low blood flow), and the exact playbook that usually unlocks it: calorie cycling, steps/NEAT, high-protein/fiber, sleep, training structure, alcohol control, and common traps.
In this episode:
 
Why belly fat is stubborn (biology + men vs women differences)
6-lever playbook: deficit audit, steps, protein/fiber, training (lift + HIIT/zone 2), sleep, alcohol pause
Traps that fool good people (recomping, hidden calories, stress bloat)
Men vs women: DHT/insulin focus vs hormonal/nutrient/stress levers
14-Day “Belly Breaker” Challenge checklist
 
This is education only — not medical advice. Stubborn fat can signal insulin resistance, cortisol issues, thyroid problems, or other conditions. Get labs (fasting insulin, HbA1c, cortisol, thyroid, sex hormones) and clinician oversight if progress stalls.
 
Open: The Belly Vendetta
Intro & Disclaimer
Why Belly Fat Is Stubborn (Biology)
Nutrition & Timing Levers
Training & Recovery Strategies
Supplements & Advanced Tools
Close: 14-Day Belly Breaker Challenge
 
🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#StubbornBellyFat #LoseBellyFat #VisceralFat #LowerBellyFat #FatLoss #WeightLoss #BodyRecomp #InsulinResistance #MetabolicHealth #NEAT #Steps #HIIT #Zone2 #StrengthTraining #Protein #Fiber #Sleep #Cortisol #AlcoholFree #Ketones #BHB #Biohacking #Nutrition #Fitness #TheHuman50Project #UltimateBiohacker10X

2 days ago


Hair Loss Prevention 2026: Real Fixes for Men vs Women (Prescriptions, Supplements, Laser, Microneedling)
Hair loss affects 85% of men and 33% of women by age 50 — but it’s not inevitable. In this Biohacker Briefing on The Human 5.0 Project, UltimateBiohacker10X breaks down the real causes (DHT patterns in men, diffuse/hormonal thinning in women), proven prevention measures, and what actually works without snake oil.
In this episode:
 
5 main types of hair loss (AGA, telogen effluvium, alopecia areata, traction, scarring)
Men vs. women: DHT-driven patterns vs. hormonal/nutrient triggers
Topicals: Minoxidil (men 5%, women 2–5%), ketoconazole shampoo, finasteride/anti-androgens
Supplements: Iron/ferritin (women priority), vitamin D, biotin (only if deficient), saw palmetto
Advanced: Low-level laser therapy (LLLT), microneedling (with minoxidil boost), PRP
Lifestyle levers: Stress reduction, protein intake, scalp hygiene
 
This is education only — not medical advice. Hair loss can signal thyroid issues, iron deficiency, autoimmune conditions, or meds. Sudden shedding, patches, scarring, or pain? See a dermatologist ASAP.
 
 
Cold Open: Not Just Genetics
Intro & Disclaimer
5 Types of Hair Loss
Men vs Women Differences
Core Prevention: Topicals & Procedures
Supplements: What Helps vs Overrated
Men vs Women Prevention Priorities
Close: Diagnosis First, Lifestyle Wins
 
🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
#HairLoss #HairLossPrevention #AndrogeneticAlopecia #Minoxidil #Finasteride #LLLT #Microneedling #HairGrowth #MenHairLoss #WomenHairLoss #Biotin #IronHairLoss #VitaminD #SawPalmetto #ScalpHealth #Biohacking #Longevity #TheHuman50Project #UltimateBiohacker10X

2 days ago

LL-37 Peptide: What It Does + Peptides It Works With (or Against):
LL-37 is your body’s master antimicrobial peptide—antibiotic, immune modulator, and wound-healing switch all in one. But it’s double-edged: powerful in infection/wound contexts, potentially inflammatory in auto-immune settings (psoriasis pathways, TLR activation).
In this Biohacker Briefing on The Human 5.0 Project, UltimateBiohacker10X breaks down:
What LL-37 really is (mechanisms in plain English)
Where human evidence actually exists (topical wound trials)
Real risks (inflammation loops, quality control, context dependence)
Peptides & factors it synergizes with (defensins, innate ensemble)
What blunts or clashes with it (salt/pH, proteolysis, biofilms, auto-inflammation)
Why “stacking” LL-37 isn’t casual — risk logic over protocol hype
This is education only — not medical advice. LL-37 research peptides are not FDA-approved for human use, quality varies wildly, and immune modulation carries real risks (e.g., paradoxical inflammation). Clinician oversight and labs required before considering anything in this space.
 
🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#LL37 #LL37Peptide #AntimicrobialPeptide #Cathelicidin #ImmuneDefense #WoundHealing #Biohacking #PeptideStacking #InnateImmunity #InflammationControl #GutHealing #SkinRepair #Psoriasis #TLR9 #Biofilm #BPC157 #TB500 #UltimateBiohacker10X #TheHuman50Project #PeptideRisks #EvidenceBasedBiohacking #HealthOptimization #Longevity #HostDefense

4 days ago

IGF-1 LR3 isn’t a “recovery peptide” — it’s a growth signal that can change the game and bite back.Tonight we separate hype from biology and break down the “Wolverine stack” like adults.
If GH peptides are the “pulse nudge,” IGF-1 LR3 is the downstream lever people chase for hypertrophy and recovery — a modified IGF-1 analog designed to drive stronger growth signaling by reducing binding to IGF binding proteins (IGFBPs).
And then the internet goes: “Cool… now stack it with PEG-MGF, TB-500, and BPC-157 and become Wolverine.”
Tonight we’re doing this like adults: mechanisms, risks, evidence quality, and the decision framework you should use before touching any growth pathway. No hype. No protocol cosplay.
Important: This episode is education only, not medical advice. Many peptides discussed online are not approved for performance/recovery uses, quality can be unreliable, and growth signaling has real tradeoffs (glucose instability, fluid shifts, and theoretical long-term concerns). If you’re considering anything that affects growth pathways, do it under qualified clinician oversight with lab monitoring.
In this episode:
What IGF-1 LR3 is (and what it’s not)
IGF-1 vs GH: “pulse signal” vs “growth execution”
Why binding proteins matter (IGFBPs)
What people report vs what to watch for (glucose symptoms, swelling, tingling)
The lab-first approach: IGF-1 trends + glucose markers + lipids
The truth about “stacks” with PEG-MGF / TB-500 / BPC-157: what’s known, what’s unknown, and why quality control is the real battlefield
Who should be extra cautious (risk profiles + when to stop)
 
🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#IGF1LR3 #IGF1 #Peptides #Biohacking #Longevity #Recovery #MuscleGrowth #Hypertrophy #InjuryRecovery #SportsScience #FitnessScience #Endocrinology #HormoneHealth #GrowthHormone #IGFBP #Glucose #HbA1c #LabWork #EvidenceBased #HealthOptimization #Healthspan #TB500 #BPC157 #PEGMGF #TendonRecovery #StrengthTraining #AthleteRecovery #TheHuman50Project #BiohackerBriefing #UltimateBiohacker10X

5 days ago

Part 2 of our GH secretagogue series: Who should NEVER touch Sermorelin, Ipamorelin, or CJC-1295 DAC—and how to get 60–80% of the same benefits naturally with sleep, protein timing, and training protocols. UltimateBiohacker10X covers real red flags (cancer history, diabetes, endocrine issues), long-term risks (glucose shifts, IGF-1 concerns), stop signals, and peptide-free levers that spike natural GH pulses without injections
Open: Flip Side of GH Peptides
Intro & Disclaimer
Who Should Avoid the GH Axis (Red Flags List)
Long-Term Risks & Monitoring
Natural Levers: Sleep Optimization (90% GH Pulses)
Protein Timing & Pre-Bed Protocol
Training for Natural GH Spikes (HIIT + Compounds)
When to Choose Natural vs. Peptides
Close: Respect the Axis, Dial Basics First
 
Track IGF-1 (200–300 ng/mL), fasting glucose, sleep scores. Lifestyle first—peptides second. Drop your natural GH hacks or lab results below!
Part 1 (Sermorelin + Ipamorelin + CJC-1295 DAC Dosing): [link to Part 1]
 
🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#GHPeptides #Sermorelin #Ipamorelin #CJC1295 #NaturalGHBoost #Biohacking2026 #AntiAging #RecoveryHacks #SleepOptimization #ProteinTiming #IGF1 #PeptideRisks #UltimateBiohacker10X #Human50Project #LongevityHacks #NoPeptidesNeeded

5 days ago

Unlock natural GH pulses without synthetic HGH risks. In this 20-min Biohacker Briefing on The Human 5.0 Project, UltimateBiohacker10X breaks down the ultimate GH secretagogue stack: Sermorelin (GHRH nudge), Ipamorelin (clean selective pulse), and CJC-1295 DAC (extended elevation).
Get conservative 2025–2026 dosing, timing principles, what to expect (sleep, recovery, body comp), cycling rules, must-have labs (IGF-1 200–300 ng/mL target), stop signals, and real talk on grey-market quality & risks.
 
Peptides vs. Hype
Intro & Disclaimer
Big Picture: GH Pulses & Aging Decline
Dosing & Timing (Sermorelin 200–300 mcg nightly, Ipamorelin 100–300 mcg, CJC-1295 DAC 1–2 mg weekly)
What Users Report + Sides to Watch
Cycling, Labs & Red Flags
Quality, Legality & Why People Get Burned
Close: Amplified Natural GH Rhythm
Track IGF-1, glucose, sleep. Run smart—measure smarter. Drop your stack results or questions below!
Part 2 coming: Who should NEVER touch GH peptides + natural levers (sleep, protein, training) that deliver 80% of the benefits peptide-free.
 
🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#Sermorelin #Ipamorelin #CJC1295 #GHStack #PeptideStack #Biohacking2026 #GrowthHormone #AntiAging #RecoveryProtocol #IGF1 #UltimateBiohacker10X #Human50Project #PeptideDosing #NaturalGHBoost
 

Monday Jan 19, 2026

The U.S. just flipped the food pyramid—protein first, ultra-processed dead last. In this 25-min drop, UltimateBiohacker10x breaks down the 2026 reset, why the old carb-base became a sickness engine, and how “eat real food” can stabilize energy, cravings, and glucose response in the real world. No fluff: a 7-day protocol, kid-proof tactics, and why this shift threatens the sick-care money machine.
 
"Eat real food” isn’t a slogan—it’s sabotage-proofingIntro & disclaimerWhy the old pyramid broke usThe 2026 reset decodedWhy it works (energy stability)CGM autonomy & your dataThe money war behind it7-Day Human 5.0 Plate ProtocolClose: power shift, not pyramid shift
 
🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
#NewFoodPyramid #Biohack2026 #MetabolicReset #RealFoodProtocol #UltimateBiohacker10X #CGMAutonomy #EatRealFood #InsulinResistance #Glucose #Nutrition #FatLoss #7DayReset#TheHuman5.0Project

Sunday Jan 18, 2026

Creatine explained for total beginners in 2026! In this quick "Creatine for Dummies" masterclass, Ultimatebiohacker10x breaks down exactly what creatine is, how the ATP-PCr reaction powers your muscles and brain, why phosphocreatine is your emergency energy buffer, real-world benefits (strength, power, focus, sleep debt recovery), best dosing (3g vs 10g+), myths busted (kidneys, bloating), and simple daily protocol.
Perfect if you're new to supplements, training hard, fighting brain fog, or just want more energy without the hype. No jargon overload — just clear science and practical tips.
Why Creatine Matters
What Is Creatine? (The Basics)
The ATP-PCr Reaction Explained
Why Phosphocreatine Is High-Energy
What Limits the System?
Quick Protocol & Pro Tips
Wrap-Up
Subscribe for more no-fluff biohacking: mind, muscle, mitochondria upgrades. Drop a comment: What's your current creatine dose? 👇
🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#Creatine #CreatineForDummies #ATP #Phosphocreatine #Bioenergetics#StrengthTraining #ExplosivePower #AthleticPerformance #MuscleScience #WorkoutScience#CreatineBenefits #MuscleGrowth #BrainHealth #Supplements2026 #PerformanceHacks #Longevity #StrengthTraining #EnergyBoost#Ultimatebiohacker10x#Thehuman5.0Project
 

Saturday Jan 17, 2026

Creatine isn't just for bodybuilders anymore — it's one of the most researched supplements for brain power, muscle growth, mood stability, and longevity in 2026. In this no-fluff masterclass, Ultimatebiohacker10x breaks down the science: history from meat extraction to Olympic gold, ATP buffering mechanism, real benefits (cognition under stress, women's cycle/menopause support, anti-inflammatory effects), optimal dosing (3g vs 10-20g strategies), kidney safety myths busted, bloating fixes, quality warnings (avoid cheap gummies!), and pro stacks like hot coffee + magnesium.
 
Intro & Why Creatine Matters
History & Discovery
ATP Buffer Mechanism
Benefits: Muscle, Brain, Women, Longevity (2026 Updates)
Dietary Sources & Saturation
Dosing War: Loading vs Maintenance
Sleep Debt, Jet Lag & Resilience
Side Effects & Fixes (Bloating, Kidneys)
Quality & Forms (Powders > Gummies)
Stacks & Synergies 
Special Cases (Women, Pregnancy, Teens)
Ultimate Protocol
Wrap-Up
Whether you're a hard-charger chasing peak performance, fighting brain fog, or optimizing for longevity — creatine is a game-changer. Evidence-based, practical, zero hype.
Subscribe for more biohacking masterclasses: high-signal upgrades for mind, body, and life.
🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#ultimatebiohacker10x #biohacking #longevity #healthspan #humanperformance #mitochondria #atp #energy #cognitivenutrition #brainhealth #focus #mentalclarity #executivefunction #neuroperformance #sleep #sleepoptimization #sleepdebt #recovery #fatigue #jetlag #circadianrhythm #supplements #creatine #creatinemonohydrate #phosphocreatine #cellularenergy #metabolichealth #strengthtraining #hypertrophy #power #athleticperformance #musclerecovery #nutrition #highperformance #resilience #stressadaptation #nootropics #wellness #fitness #healthpodcast #biohacker #upgradeyourlife

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