The Human 5.0 Project

The Human 5.0 Project is the podcast where science meets self-optimization. Hosted by Ultimate Biohacker 10X, this show explores the real research, real data, and real dosing behind today’s most effective biohacking tools — from peptides, longevity molecules, and nootropics to recovery devices, lifestyle strategies, sleep optimization, training principles, and cutting-edge performance tech.

Each episode breaks down complex biology into practical, actionable protocols you can use to improve energy, metabolism, cognition, and overall healthspan. No hype. No fluff. Just evidence-based insights for people who want to understand their bodies, upgrade their biology, and unlock their highest potential.

If you’re ready to optimize your life one pathway at a time, you’re in the right place.

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Episodes

Tuesday Dec 23, 2025

Pinealon is a Russian tri-peptide bioregulator developed for military brain resilience that’s now gaining global attention for neuroplasticity, brain fog, Long COVID cognition, and healthy aging in 2025.
Originally created by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, Pinealon has over 40 years of research and real-world use behind it.
In this episode of The Human 5.0 Project, we break down:• The full history of Pinealon from Soviet labs to modern clinics• Decades of Russian research plus a 2024 Italian human pilot study• How Pinealon supports BDNF, melatonin rhythm, EEG normalization, and neuroplasticity• Exact dosing and cycle frameworks (preventative vs aggressive neuro-recovery)• Best stacking strategies with Semax, Selank, Dihexa, and Cerebrolysin• Safety, tolerability, and who should avoid it
If you’re dealing with brain fog, post-viral cognitive decline, TBI recovery, or want to preserve cognitive performance as you age, this episode gives you the full picture.
📄 Download the free Pinealon Dosing + Stack PDF
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
💬 Comment below: What’s your #1 brain goal for 2026?
🔔 Subscribe for weekly deep dives on peptides, longevity, and root-cause medicine.
This is for informational purposes only and is not medical advice.
 
 
 
#Pinealon#BrainBioregulator#Neuroplasticity#BrainFog#LongCOVID#RussianPeptides#Khavinson#BDNF#CognitiveHealth#AntiAgingBrain#Semax#Selank#Dihexa#Cerebrolysin#Human50Project#Human 5.0Project

Tuesday Dec 23, 2025

Semax and Selank (often labeled C-Max and C-Link) are Russian nootropic peptides dominating 2025 Long COVID, brain fog, and anxiety protocols.
Developed in Moscow over 30 years ago, these peptides are prescription medications in Russia but remain research-only in the United States.
In this episode of The Human 5.0 Project, we break down:• The full history and 300+ Russian studies• How Semax increases BDNF and neuroplasticity• How Selank calms anxiety without sedation• Why they’re being used in Long COVID and post-viral brain fog• How they stack with Dihexa, Cerebrolysin, and Pinealon• The global regulatory status in 2025
If you want your brain back without stimulants or benzodiazepines, this is worth understanding.
📄 Free Semax + Selank Protocol PDF
 
👉 For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
🧬 And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
💬 Comment below: Semax or Selank first?
🔔 Subscribe for weekly deep-dives on peptides, longevity, and root-cause medicine.
 
 
#Semax #Selank #CMax #CLink #LongCOVID #BrainFog #Neuroplasticity#RussianPeptides #BDNF #NootropicPeptides #PostViralFatigue#Cerebrolysin #Dihexa #Pinealon #AnxietyRelief#FunctionalMedicine #Biohacking #LongevityPeptides#Human50Project#Human5.0Project

Monday Dec 22, 2025

 
SS-31 (Elamipretide) in 2025: The FDA-Approved Mitochondrial Reset for Long COVID and ME/CFS
 
Description:Welcome back to The Human 5.0 Project! In this episode, we dive into SS-31 (Elamipretide) — the peptide that became the first FDA-approved mitochondrial repair therapy for a rare disease in 2025, and how it’s transforming our understanding of fatigue medicine.
In this episode, we cover:
Why SS-31 exploded in 2025 and the human data behind it
How SS-31 works inside mitochondria to restore energy production and reduce post-viral crashes
The exact labs that show it’s working and the research-grade protocols used in trials
What the FDA approval for Barth syndrome means and why SS-31 is still off-label for Long COVID and ME/CFS
If you’re struggling with relentless fatigue or know someone who is, this episode is for you.
📥 Download the free SS-31 Protocol Guide (labs, stacks, dosing frameworks):
🔔 Subscribe for more cutting-edge biohacking insights.
 
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
 
 
#SS31 #Elamipretide #MitochondrialHealth #LongCOVID #ME/CFS #FatigueRecovery #FDAApproved #Mitochondria #Biohacking #FunctionalMedicine #ChronicFatigue #HealthTech #Human5.0Project #MitochondrialRepair #EnergyReset#Human50Project
 
 
 
 

Monday Dec 22, 2025

TB-500 + TB4: Rapid Joint Repair, Hair Growth Signals, and Brain Fog Improvements? What 2025 Data Shows
TB-500 and Thymosin Beta-4 (TB4) are peptides originally studied for tissue repair and immune signaling — and in 2025, they’re gaining attention for their potential roles in joint recovery, hair density support, and cognitive clarity.
In this episode of The Human 5.0 Project, we break down:• What TB-500 and TB4 actually do at the cellular level• 2025 human and pilot data on tendon healing, inflammation reduction, and neurovascular support• Why athletes, clinicians, and biohackers are using these peptides as part of a repair-first strategy• Early findings in brain fog and post-viral cognitive symptoms• Safety, legality, and lab markers to monitor
These peptides aren’t magic — but they may act as part of the body’s natural repair crew when used responsibly and under supervision.
🔗 Full episode link in bio📄 Free TB-500 + TB4 cheat sheet 
 
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
⚠️ Educational content only. Not medical advice.
 
 
#TB500#TB4#ThymosinBeta4#PeptideTherapy#InjuryRecovery#BrainFog#HairGrowth#Longevity#Biohacking#JointHealth#Neuroprotection#FunctionalMedicine#LongCOVID#PeptideHealing#Human50Project

Sunday Dec 21, 2025

If you’ve had COVID and now feel like your brain is wrapped in cotton — words vanish mid-sentence, simple tasks feel overwhelming, and mental fatigue hits after just minutes — you’re not alone.
This is Long COVID brain fog, still affecting an estimated 10–20% of everyone infected since 2020 — over 100 million people worldwide.
In this deep-dive episode of The Human 5.0 Project, we break down what’s actually happening in the brain, why many standard evaluations miss it, and the 2025 clinical and functional medicine protocols that are helping people recover cognitive clarity.
In this episode, you’ll learn:
• The 2025 clinical picture of Long COVID brain fog, including the cognitive triad neurologists recognize• Why it happens: persistent spike protein fragments, micro-clots, mast-cell activation, and mitochondrial shutdown• The labs most doctors skip (hs-CRP, D-dimer, omega-3 index, NAD proxies)• Proven 2025 modalities being used right now: nicotine patches, peptides (BPC-157, SS-31, VIP nasal), HBOT, red-light therapy, guanfacine, and more• Diet and supplement stacks that actually move the needle (nattokinase, NAC, cyclical keto, PEA)• A realistic 90-day “get my brain back” decision tree
If you’re dealing with focus loss, word-finding difficulty, mental crashes after exertion, or know someone who is — this episode gives you the tools clinics and researchers are using now.
📥 Download the free Long COVID Brain Fog Reversal Checklist(longevity website):👉 BiohackerDepot.com
🧬 Research-grade tools:👉 PeptideSphere.com
💬 Comment below: What’s your #1 brain fog symptom?🔔 Subscribe for root-cause biohacking — next up: Hashimoto’s reversal protocols.
 
 
#LongCOVID#BrainFog#LongCOVIDBrainFog#PostCOVID#LongCOVIDRecovery#CognitiveHealth#PostViralFatigue#FunctionalMedicine#Biohacking#PeptideTherapy#HBOT#NicotinePatch#Nattokinase#RedLightTherapy#Human50Project

Sunday Dec 21, 2025

"Unveiling the Hidden Causes and Advanced Approaches for Better Thyroid Health"
In this episode of The Human 5.0 Project, we dive deep into Hashimoto’s thyroiditis, exploring the hidden causes that mainstream medicine often overlooks. Discover why T4-only therapy may not be enough, the importance of comprehensive lab testing, and cutting-edge strategies that are changing the way we approach thyroid health in 2025.
Key Points:
The hidden timeline of Hashimoto’s and why early immune markers matter.
Why standard treatments often fail and the role of T3 and desiccated thyroid.
Innovative peptide therapies and lifestyle interventions that are paving the way for better outcomes.
Let’s raise the standard of care: Labs first. Meds when necessary. Personalized healing always.
Hit subscribe—next week we decode long-COVID brain fog.
Download the free Hashimoto’s Reversal Checklist
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#Hashimotos #HashimotosThyroiditis #ThyroidHealth #AutoimmuneThyroid #HashimotosAwareness #ThyroidLabs #TPOAntibodies #ReverseT3 #FunctionalMedicineThyroid #RootCauseThyroid #GlutenFreeHashimotos #LDNThyroid #ThymosinAlpha1 #BPC157Thyroid #SeleniumForThyroid #MyoInositolHashimotos #T3Therapy #DesiccatedThyroid #HypothyroidismTreatment #AutoimmuneReversal #BiohackingThyroid #WomensThyroidHealth #LongevityThyroid #MetabolicHealth #FunctionalMedicine #PeptideTherapy #Human50Project #UltimateBiohacker10X

Wednesday Dec 10, 2025

Is depression really a “serotonin problem”… or something your doctor didn’t check?In today’s episode, we’re breaking down the five real biological and lifestyle pathways that can mimic depression—and why SO many people get put on meds before anyone even runs basic labs.
As a retired MD who has seen countless rushed admissions and missed diagnoses, I’m pulling back the curtain on what depression often really is:• Metabolic dysfunction• Nutrient deficiencies• Inflammatory brain stress• Loneliness-driven cortisol overload• Medication side effects
This deep dive gives you the exact roadmap to identify root causes before going down the trial-and-error medication path.
In this episode you’ll learn:
• The $29–$89 labs to run right now (TSH, ferritin, B12, hs-CRP, omega-3 index)• Why magnesium glycinate can calm glutamate-driven anxiety better than you think• How the UCLA Loneliness Scale identifies social isolation depression• Why post-COVID depression often needs metabolic repair (T3 + berberine) instead of SSRIs• The hidden drug interactions that can worsen mood (like statins depleting CoQ10)
If you’ve ever wondered why standard antidepressants don’t always work—or why someone you love still struggles despite being “treated”—this episode is a must-watch.
Let’s raise the standard of care: Labs first. Meds when necessary. Personalized healing always.
Hit subscribe—next week we decode long-COVID brain fog.
 
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#Depression #MentalHealth #RootCauseMedicine #MetabolicHealth #LabTesting #FunctionalMedicine #PostCovid #Inflammation #HormoneHealth #Ferritin #B12Deficiency #ThyroidHealth #Cortisol #BrainHealth #AnxietyRelief #Longevity #HealthOptimization #Biohacking #NutrientDeficiency #HolisticHealth #DepressionLabs #SSRIFail #ThyroidDepression #B12Crash #InsulinResistanceMood #PhysicianPodcast #MentalHealthHack #BiohackingDepression #Omega3Index #CortisolRhythm #MagnesiumForMood #LonelinessEpidemic #PostCovidFog #CoQ10Deficiency #PsychWardExitPlan #UltimateBiohacker10X #Human50Project #RootCauseFix #AshwagandhaWins

Wednesday Dec 10, 2025

 
Microplastics are now in our food, water, air—even our bloodstream. In this episode, we break down exactly where microplastics come from, how they enter the human body, the health risks they pose, and the emerging science on removing them.
We also cover:• The top home and lifestyle sources of microplastics• How to detox microplastics naturally• What works, what doesn’t, and what’s emerging• House and lifestyle upgrades to reduce plastic load• How microplastics affect hormones, inflammation, mitochondria, fertility, and aging• Biohacker strategies to protect your cells and extend your healthspan
If you care about longevity, detoxification, and metabolic performance, this is a must-watch.
Comment below: What shocked you most about microplastics?
 
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#Microplastics #Detox #Healthspan #Longevity #Biohacking #Toxins #EnvironmentalHealth #NAD #Glutathione #HormoneDisruption #EndocrineDisruptors #UltimateBiohacker10X #HumanFiveProject #PFAS #Nanoplastics #CleanLiving

Tuesday Dec 09, 2025

The Cellular Energy Masterclass: NAD+ Precursors for Peak Performance & Healthspan
In this deep-dive episode, we break down the full science behind NAD+, the molecule your mitochondria depend on for energy, repair, and metabolic resilience. We compare major NAD+ precursors—NMN, NR, Niacin, Niacinamide, NADH—and explain how each works, how they differ, and how to use them strategically for peak performance and extended healthspan.
🔥 What you’ll learn:• What NAD+ actually does inside your cells• Why NAD+ declines with age — and how to reverse it• NMN vs NR vs Niacin vs NADH: Mechanisms & differences• Dosing strategies for energy, recovery, and longevity• Synergistic stacks for mitochondrial upgrade• How NAD+ precursors fit into a full biohacking system• The latest research on healthspan extension
 
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#NAD #NADPlus #NMN #NR #Niacin #NADH #Biohacking #Longevity #AntiAging #Mitochondria #EnergyProduction #Healthspan #CellularEnergy #UltimateBiohacker10X #Human5.0Project #Human5Project

Monday Dec 08, 2025

GLP-1 Showdown: Semaglutide vs Tirzepatide vs Retatrutide (+ Cagrilintide, Mazdutide, Survodutide) | Ultimate Biohacker 10X
In today’s episode of The Human 5.0 Project, we break down the ultimate incretin showdown — the real science behind the world’s most powerful metabolic and longevity drugs. Whether you're exploring Semaglutide, Tirzepatide, Retatrutide, CagriSema (Cagrilintide + Semaglutide), Mazdutide, or Survodutide, this episode gives you everything you need to understand which one fits your goals.
🔥 What You'll Learn:• How GLP-1, GIP, glucagon, and amylin pathways really work• Which compounds deliver the highest weight-loss percentages• Longevity benefits: inflammation reduction, heart protection, metabolic reset• Side effects, management strategies, titration tips• How biohackers integrate these with peptides, supplements & lifestyle stacks• Which drug is best for fat loss vs metabolic healthspan• What’s coming in 2025–2027: the future of incretin therapy
If you’ve wondered why people are losing 15–24% of their body weight… or how these compounds might extend your healthspan, this is the episode for you.
👉 Longevity protocols & stacks: https://biohackerdepot.com👉 Research-grade peptides & agonists: https://peptidesphere.com
 
#GLP1 #Semaglutide #Ozempic #Wegovy #Tirzepatide #Mounjaro #Zepbound #Retatrutide #Cagrilintide #CagriSema #Mazdutide #Survodutide #WeightLoss2025 #MetabolicHealth #Longevity #Biohacking #FatLoss #HealthSpan #IncretinTherapy #AntiAging #PeptideTherapy #UltimateBiohacker10X #Human50Project #MetabolicReset
 

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