The Human 5.0 Project

NAD+ Explained: NMN vs NR vs Niacin — The Ultimate Longevity Breakdown (2025)

The Cellular Energy Masterclass: NAD+ Precursors for Peak Performance & Healthspan
In this deep-dive episode, we break down the full science behind NAD+, the molecule your mitochondria depend on for energy, repair, and metabolic resilience. We compare major NAD+ precursors—NMN, NR, Niacin, Niacinamide, NADH—and explain how each works, how they differ, and how to use them strategically for peak performance and extended healthspan.
🔥 What you’ll learn:• What NAD+ actually does inside your cells• Why NAD+ declines with age — and how to reverse it• NMN vs NR vs Niacin vs NADH: Mechanisms & differences• Dosing strategies for energy, recovery, and longevity• Synergistic stacks for mitochondrial upgrade• How NAD+ precursors fit into a full biohacking system• The latest research on healthspan extension
 
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#NAD #NADPlus #NMN #NR #Niacin #NADH #Biohacking #Longevity #AntiAging #Mitochondria #EnergyProduction #Healthspan #CellularEnergy #UltimateBiohacker10X #Human5.0Project #Human5Project

The Ultimate GLP-1 And Incretin Showdown: Semaglutide, Tirzepatide, Retatrutide (+ Cagrilintide, Mazdutide, Survodutide)

GLP-1 Showdown: Semaglutide vs Tirzepatide vs Retatrutide (+ Cagrilintide, Mazdutide, Survodutide) | Ultimate Biohacker 10X
In today’s episode of The Human 5.0 Project, we break down the ultimate incretin showdown — the real science behind the world’s most powerful metabolic and longevity drugs. Whether you're exploring Semaglutide, Tirzepatide, Retatrutide, CagriSema (Cagrilintide + Semaglutide), Mazdutide, or Survodutide, this episode gives you everything you need to understand which one fits your goals.
🔥 What You'll Learn:• How GLP-1, GIP, glucagon, and amylin pathways really work• Which compounds deliver the highest weight-loss percentages• Longevity benefits: inflammation reduction, heart protection, metabolic reset• Side effects, management strategies, titration tips• How biohackers integrate these with peptides, supplements & lifestyle stacks• Which drug is best for fat loss vs metabolic healthspan• What’s coming in 2025–2027: the future of incretin therapy
If you’ve wondered why people are losing 15–24% of their body weight… or how these compounds might extend your healthspan, this is the episode for you.
👉 Longevity protocols & stacks: https://biohackerdepot.com👉 Research-grade peptides & agonists: https://peptidesphere.com
 
#GLP1 #Semaglutide #Ozempic #Wegovy #Tirzepatide #Mounjaro #Zepbound #Retatrutide #Cagrilintide #CagriSema #Mazdutide #Survodutide #WeightLoss2025 #MetabolicHealth #Longevity #Biohacking #FatLoss #HealthSpan #IncretinTherapy #AntiAging #PeptideTherapy #UltimateBiohacker10X #Human50Project #MetabolicReset
 

Nature vs. Pharma: Why Your Body Prefers Pathways Over Drugs | Ultimate Biohacker 10X Explains

Are synthetic drugs silently overwhelming your body’s detox machinery?In this episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks down the real difference between natural biological pathways and lab-created pharmaceuticals — and why your body reacts so differently to each one.
We dive deep into how the liver’s cytochrome P450 enzymes act as your internal garbage disposal system, processing hormones, toxins, plant compounds… and unfortunately, most pharmaceutical drugs. When these enzymes get overloaded, everything from hormone balance to detoxification to metabolic health starts breaking down.
Inside this episode you’ll learn:
🔥 Why peptides and biologics feel “cleaner” in the body🔥 How synthetic drugs create artificial pathways your physiology must fight to control🔥 Why beta blockers, SSRIs, and statins overwhelm the P450 enzymes🔥 How natural compounds amplify existing pathways instead of creating new ones🔥 What J.P. got right about metabolic overload and enzyme burnout🔥 How to protect your cytochrome P450 system for longevity, performance, and hormone balance🔥 Why compounds like SLU-PP-332 work with — not against — your biology🔥 And how to know when a drug is helping you… or quietly hurting you
This is the episode that bridges ancient biological wisdom with cutting-edge biohacking science. If you want to understand why your supplements work differently than your prescriptions — and why nature’s blueprint is still the gold standard — this deep dive is for you.
👉 For peptide protocols and framework stacks, visit biohackerdepot.com👉 For research-grade material and advanced optimization tools, go to peptidesphere.com
Drop a comment below: Are you team nature or team pharma?Subscribe for more deep dives into metabolic health, longevity, peptides, and Human 5.0 upgrades.
 
Click HERE for the free P450 Power Stack
 
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#Biohacking #UltimateBiohacker10X #Human5Project #NaturalPathways #Pharmaceuticals #CytochromeP450 #LiverDetox #Peptides #BPC157 #SLUPP332 #Longevity #MetabolicHealth #HormoneBalance #FunctionalMedicine #Mitochondria #HealthOptimization #NaturopathicMedicine #CleanSupplements #Biologics #DrugMetabolism #Healthspan #SideEffects #Detoxification #HolisticHealth #EvolutionOfHealth
 

SLU-PP-332: The Future of Exercise in a Pill!

In this episode of The Human 5.0 Project, we dive deep into SLU-PP-332, a groundbreaking compound that promises to revolutionize metabolic health and longevity. Dosing in notes.
What You’ll Learn:
Origins and Development: Discover how SLU-PP-332 was developed at Saint Louis University and the brilliant minds behind it.
Mechanism of Action: Learn how this compound mimics exercise at the cellular level, boosting mitochondrial function and metabolic health.
Current Applications: Explore the therapeutic uses of SLU-PP-332 and how it compares to other metabolic therapies.
Dosing: Research dosing is oral capsule, 500 µg daily in one or split doses
Future Prospects: Get a sneak peek into ongoing research and what the future holds for this promising compound.
Join us as we explore the science, benefits, and potential of SLU-PP-332. Don’t forget to like, comment, and subscribe for more deep dives into the latest in biohacking and longevity!
 
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#SLUPP332 #ExerciseInAPill #Biohacking #Longevity #MetabolicHealth #Mitochondria #ERRAgonist #FatLoss #AntiAging #HealthTech #HumanOptimization #PeptideTherapy #ResearchScience #FutureOfHealth

ALS Unveiled: Navigating Supportive Therapies and Future Innovations

In this episode of the Human 5.0 Project, we delve into the complex world of ALS (amyotrophic lateral sclerosis). We start with a brief overview of what ALS is, and then we explore the current standard treatments, including medications like Riluzole and Edaravone. The heart of the episode focuses on the innovative supportive therapies being used in the U.S.—from functional medicine and nutritional supplements to cutting-edge peptides and their role in supporting neuron health. We also look into the exciting research and future directions, including stem cell therapies and their potential to transform ALS care. Join us as we uncover the latest advancements and hopeful strategies in the fight against ALS.
 
If you want to contact Shanghai East Hospital about their ALS stem cell trial, you can email them at reception1f@seimc.com.cn or call their 24-hour reception at +86 21 5879 9999. If you want to reach out to Dr. Jun Xu, who’s involved in their ALS research, you can email him at xunymc2000@yahoo.com or call his office at 021-65982412. It’s always a good idea to contact them directly to check eligibility and any international participation details.
 
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#ALS #Neurodegeneration #FunctionalMedicine #Peptides #StemCellTherapy #NeuroHealth #ALSResearch #Longevity #HealthInnovation #Biohacking

Nicotine: The Truth Behind the ‘Addictive’ Label, COVID-19 Spike Proteins & The Science They Never Told You

In this episode of The Human 5.0 Project, we unpack one of the most controversial molecules in modern medicine: nicotine.Not smoking. Not vaping. Nicotine itself.
For decades, nicotine has been labeled as “highly addictive” by the FDA and Surgeon General—but emerging research from the 1990s through 2025 paints a far more complex picture. We dive into:
🔬 What the science actually shows: 1990s–2025
• Big Tobacco documents revealing how additives—not nicotine—supercharged dependence• Why pure nicotine behaves differently from cigarette-delivered nicotine• How NRT (patches, gum) shows almost zero abuse potential• Neuroprotective effects in Alzheimer’s, Parkinson’s, ADHD & cognitive performance
⚡ The Addiction Debate: Is Nicotine Addictive Alone?
We break down:• The dopamine pathway• Role of cues, rituals, and pyrazines• Why animal studies struggle to show self-administration• Cutting-edge 2021–2025 meta-analyses challenging the old narrative
🧬 Nicotine vs. Spike Protein — The Cellular Battle No One Expected
You’ll learn about the wild (but surprisingly plausible) “nicotinic hypothesis”:• Spike proteins sharing toxin-like motifs with snake venom neurotoxins• How SARS-CoV-2 may target nicotinic acetylcholine receptors (nAChRs)• 2023–2024 studies showing nicotine potentially reducing spike binding, modulating inflammation, and protecting the brain• What simulations, mouse studies, and in-silico models reveal about nicotine competing with spike proteins
This episode cites Nature (2023), ACS Chemical Neuroscience (2023), PNAS (2020–2022), NIH reviews, and WHO/FDA reports — bringing 30+ years of research into one place.
🎧 Why this matters for YOU:
Whether you’re exploring NRT for cognitive enhancement, quitting smoking, biohacking inflammation, or curious about spike-protein pathology — this episode flips the script on nicotine’s true identity.
 
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
 
#Nicotine #NicotineResearch #NicotineAddiction #Biohacking #Longevity #HealthPodcast #SciencePodcast #SpikeProtein #SARSCoV2 #nAChR #CholinergicSystem #Neuroprotection #Cognition #SmokingCessation #NRT #VagusNerve #Inflammation #Neuroscience #NatureResearch #PandemicScience #HumanOptimization #WellnessScience #SnakeVenomTheory #NicotineDebate

Thymosin Alpha-1 (TA1) in 2025: Dosing for Immunity, Autoimmune & Longevity + Best Stacks

Welcome back to The Human 5.0 Project! In today’s episode, we’re diving deep into Thymosin Alpha-1 (TA1)—the immune-modulating peptide that’s been quietly revolutionizing immune resilience for decades.
We cover:
The fascinating history of TA1: From its discovery in the 1970s to its role in 2025 as a trusted tool for biohackers and longevity enthusiasts.
How TA1 works: We break down how this 28-amino-acid peptide acts as the conductor of your immune system, fine-tuning T-cells, NK cells, and cytokines for a balanced, anti-inflammatory response.
Dosing protocols for everything from acute viral infections to autoimmune conditions and long-term longevity stacks.
Stacking TA1: Learn how to pair TA1 with LDN, vitamin D, zinc, BPC-157, and more for enhanced immune support, lung repair, and longevity.
Biohacking insights: How the community is using TA1 as a seasonal reset and the latest microdosing trends.
Safety tips, best practices, and a full TA1 playbook are all inside.
👉 Watch now to learn why TA1 is the immune peptide you need in your longevity toolkit!
 
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides like TA1, peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#ThymosinAlpha1 #TA1 #ImmuneSystem #Peptides #Biohacking #Longevity #ImmuneHealth #Wellness #HealthOptimization #ImmuneBoost #Thymosin #PeptideTherapy #Autoimmune #AntiInflammatory #ViralInfections #HealthScience #BiohackerLife

Semaglutide Simplified: From Ozempic to Healthspan Hero

In this 9-minute episode, we break down Semaglutide (Ozempic/Wegovy/Rybelsus) — the GLP-1 agonist that reshaped weight loss, longevity, and metabolic health. Even as newer peptides like Tirzepatide and Retatrutide enter the spotlight, Semaglutide remains a proven, reliable, and highly effective tool for weight management and healthspan optimization.
We cover everything you need to know:✔️ What Semaglutide is & how it works✔️ Why it’s STILL relevant despite newer multi-agonists✔️ Dosing protocols for weight loss & diabetes✔️ Side effects & how to minimize them✔️ The best stacks for muscle retention, longevity, & metabolic health✔️ The 2025 biohacking trend: microdosing GLP-1s for longevity✔️ Safety considerations & where the future of GLP-1 therapy is headed
 
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides like Semaglutide, peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
If you enjoy deep dives into peptides, metabolism, and human optimization, don’t forget to like, subscribe, and share!
 
#Semaglutide #Ozempic #Wegovy #Rybelsus #GLP1 #WeightLoss #HealthOptimization #Biohacking #Longevity #MetabolicHealth #FatLossJourney #Microdosing #HealthSpan #Tirzepatide #Retatrutide #Peptides #HumanPerformance #WellnessScience #PeptideTherapy #HormoneHealth

Retatrutide Revolution: The Triple-Threat Agonist Redefining Weight Loss & Beyond

Welcome back to The Human 5.0 Project – where we upgrade the human operating system.
In today’s episode we go full-send on Retatrutide , Eli Lilly’s triple-agonist that just obliterated every weight-loss record in 2025: up to 24.2% body weight loss in 48 weeks (that’s 50–60+ lbs for most people) with simultaneous improvements in A1c, liver fat, blood pressure, and triglycerides. People are already calling it the “Ozempic killer” and the first true “programmable metabolism” molecule.
Here’s exactly what we cover in this 9-minute deep dive:
What Retatrutide actually is (GLP-1 + GIP + Glucagon triple action explained simply)
Why the glucagon receptor makes it burn fat differently than Semaglutide or Tirzepatide
Real phase-2/phase-3 dosing schedules (0.5 mg → 12 mg titration)
The smartest peptide & supplement stacks in 2025 (Tesamorelin, CJC/Ipamorelin, BPC-157, NMN, berberine, etc.)
How the biohacking underground is microdosing it (0.25–1 mg pulses) for slow, sustainable, rebound-proof results
Current safety profile & what to watch for
If you’re into fat-loss, metabolic longevity, or just want to see what the next generation of incretin drugs can actually do, this is the episode.
 
Drop a comment: Are you Team Tirzepatide or jumping straight to Retatrutide when it drops? 👇
 
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides like Retatrutide, peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#Retatrutide #TripleAgonist #WeightLoss2025 #OzempicKiller #GLP1 #Biohacking #Longevity #FatLoss #MicrodosingPeptides #MetabolicHealth #EliLilly #Human50 #PeptideStack #Type2Diabetes #LiverHealth #HealthSpan
 

GHK-Cu Unleashed: Copper Peptide Magic for Skin, Healing, and Beyond

In this 5-minute deep dive, we unpack GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper), the copper-bound tripeptide that’s absolutely dominating 2025 longevity and aesthetic medicine conversations. Once a well-kept secret of high-end skincare, GHK-Cu is now the #1 most-researched regenerative peptide worldwide — and for good reason.
Here’s exactly what we cover:
Why natural GHK levels drop from ~200 ng/mL in your 20s to under 20 ng/mL by age 60… and how GHK-Cu reverses that decline
Injectable vs. topical: real-world differences in absorption, dosing, and results (including scar remodeling, wrinkle reduction, and hair regrowth data)
The 7 core mechanisms: gene modulation (4,000+ genes), collagen/elastin explosion, antioxidant superpower, anti-inflammatory effects, angiogenesis, wound-healing acceleration, and epigenetic reset
Systemic benefits beyond skin: lung fibrosis reversal, nerve regeneration, cardiovascular protection, liver/kidney support, and bone density
Top longevity stacks in 2025: GHK-Cu + Epitalon, BPC-157, NMN/NAD+, Thymosin Alpha-1, retinoic acid combos, and more
Current research dosing protocols (injectable cycles, topical strengths, and timing tricks)
If you’re into biohacking, age-reversal skincare, injury recovery, or just want to look and feel 10–15 years younger, this is the episode you’ve been waiting for.
 
Drop a comment: are you team injectable or team topical? 👇
 
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
 
And if you're sourcing research peptides like GHK-Cu, peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
 
#GHKCu #CopperPeptide #AntiAging #SkinRejuvenation #PeptideTherapy #Biohacking #Longevity #WoundHealing #HairGrowth #Collagen #Epigenetics #HealthSpan #RegenerativeMedicine #2025Biohacking #AntiAging #CollagenBoost